Gordan Lauc, PhD is a Professor of Biochemistry and Molecular Biology at the University of Zagreb Faculty of Pharmacy and Biochemistry and the owner of Genos Ltd. Dr. He has researched in the field of glycobiology for over 20 years already, and his current interest is focused on the complex genetics of protein glycosylation and the role of alternative glycosylation in physiological and pathophysiological processes. His laboratory performed the first population study of the human plasma glycome, which revealed a significant variability in glycome composition between individuals. At the same time, composition of the glycome within an individual was found to be remarkably stable. The introduction of high-throughput studies of the glycome enabled glycomics to meet modern genomics and Dr. Lauc led the first genome wide association study of the human plasma glycome. Furthermore, the laboratory od Dr. Lauc performed the first large scale study of the glycome of an individual protein, in this case human IgG. This study revealed that on the level of an individual protein, variability of glycosylation is even larger than for the total plasma glycome. Genome wide association studies of the IgG glycome, and a number of diagnostic and prognostic biomarker studies (diabetes, colorectal cancer, ulcerative colitis, etc) are currently in progress.
Dr. Maja Pučić Baković is the Head of the Glycobiology Laboratory in Genos Ltd. Majority of her research work in the Glycobiology Laboratory is the analysis of plasma protein N-glycans by Ultra Performance Liquid Chromatography (UPLC).
Jasminka Krištić is PhD student-researcher in the Glycobiology Laboratory at Genos Ltd where she is working on HighGlycan project. Her research includes UPLC IgG glycosylation profile analysis. She is also working on functional genomics of glycosylation as part of an international collaboration. In the Analytical DNA Laboratory she is in charge of pyrosequencing analysis of genetic risk factors for thrombosis, lactose intolerance and for creating new genetic assays using pyrosequencing technology.
She is involved in research of epigenetic regulation of glycosylation within FP7 project HighGlycan, which is at the same time the subject of her future doctorate dissertation/thesis. The epigenetic part of her research includes analysis of methylation of HNF1α gene, the key protein in regulation of glycosyltransferase transcription, and its function is proper positioning and glycosylation of GLUT2 transporter on the membrane of β cells of pancreatic Langernhans islets. Due to that, the research is oriented toward the analysis of methylation status, in particular of pancreatic cells, which could complement earlier discoveries about MODY type of diabetes. Namely, disrupted glycosylation of GLUT2 transporter, caused by change in methylation status of the observed region, affects function of β cells of Langernhans islets and is one of possible causes for occurrence of MODY type of diabetes.
A researcher and PhD student in the Glycobiology Laboratory in Genos Ltd. His field of research is within FP7 HighGlycan and consists of glycan isolation methods from various biological samples which are subsequently analysed and connected to phenotypes. He is also involved in animal genome analysis in Genos DNA laboratory.
She is biochemist and analytical chemist working as a researcher and PhD student in Glycobiology Laboratory at Genos Ltd. She is working on development of methods for high-throughput analysis of glycans as part of FP7 HighGlycan project. Since she is the only chemist in the research group, her daily tasks are observing experiments from the point of view of chemistry.
She is a PhD student in the Glycobiology Laboratory of Genos Ltd. with interest in biostatistics. With training in both molecular and computational biology, she is focused on data mining and statistical analyses of glycomics data. To gain a deeper understanding concerning the manners in which glycans may affect human health, she is currently working on clustering analysis of human plasma and IgG N-glycome, as well as on exploratory data analysis of human glycome.
He is a graduate student in Laboratory for Glycobiology in Genos Ltd., working on integrative analysis of genomics and glycomics data as part MIMOMICS and IBD-BIOM projects. His research interests include statistical genetics and computational biology. He is in particular interested in gene regulation networks and variations in regulatory DNA that have important role in glycosilation of IgG protein.
He is a PhD student in the Glycobiology Laboratory of Genos Ltd. His field of research is within PAIN-OMICS project and consists of glycan isolation methods from various biological samples which are subsequently analysed and connected to pain.
Researcher involved in the ‘Human Neuroglycome’ project which is funded as part of the NewFelPro initiative (Republic of Croatia and European Union). The aim of this project is to characterise the pattern of glycosylation in various regions of the human brain throughout ontogeny and thus to gain an understanding of the importance of various glycan structures in neurobiological processes.
Olga's interests in research include: evolutionary biology, human genetics, methods of high-throughput analysis of glycans, as well as sequencing of new generation. The aim of her project is to investigate relations between glycosylation of immunoglobulin and reaction of immune system.
Master of Science in Molecular Biology, she has worked in the Glycobiology Laboratory of the company Genos since 2015. Within the project Pain-OMICS, she is involved in research of glycans isolated from biological samples, in their analysis and in determining their connection with pain in the lower back among patients.