Prof. dr. sc. Gordan Lauc

Predsjednik uprave i stalni sudski vještak

Biografija

Prof. dr. sc. Gordan Lauc, utemeljitelj i predsjednik uprave tvrtke Genos d.o.o., jedan je od vodećih europskih znanstvenika u području glikobiologije. Zbog nedostatka adekvatnih analitičkih metoda, značajni dio rada Prof. dr. sc. Gordana Lauca usmjeren je na razvoj metoda za analizu glikana i njihove kasnije primjene u istraživanju ljudskih bolesti.

Najveća prekretnica u glikobiologiji dogodila se 2008. godine s razvojem prve kvantitativne visokoprotočne metode za analizu glikana. Upravo je Prof. dr. sc. Lauc bio prvi koji je shvatio kako bi ova metoda mogla omogućiti glikomici da se pridruži visokoprotočnoj genomici u cjelogenomskim asocijacijskim studijama. Kako je sudjelovao u razvoju te metode, njegov je laboratorij bio drugi u svijetu koji ju je i predstavio te prvi koji ju je primijenio na velikom broju ljudskih uzoraka u jednoj opsežnoj studiji o varijabilnosti u glikomu ljudske plazme. On je isto tako inicirao suradnju između grupa koje se bave visokoprotočnom genetikom i glikomikom što je omogućilo prve uvide u složenu genetiku glikolizacije proteina kod čovjeka. Objavio je preko 70 znanstvenih radova u stranim stručnim časopisima i dobitnik je brojnih domaćih i međunarodnih (FP6, FP7, NIH) financijskih potpora za istraživanje.

Odabrane publikacije 

  1. Huffman JE, Knežević A, Vitart V, Kattla J, Adamczyk B, Novokmet M, Igl W, Pučić M, Zgaga L, Johannson A, Redžić I, Gornik O, Zemunik T, Polašek O, Kolčić I, Pehlić M, Koeleman CAM, Campbell S, Wild SH, Hastie ND, Campbell H, Gyllensten U, Wuhrer M, Wilson JF, Hayward C, Rudan I, Rudd PM, Wright AF, Lauc G (2011) Polymorphisms in B3GAT1, SLC9A9 and MGAT5 are associated with variation within the human plasma N-glycome of 3533 European adults. Human Molecular Genetics, 20(24):5000-5011. (IF=8,058; rank 13/156 – Genetics and Heredity, median IF = 2,488)

  2. Pučić M, Knežević A, Vidič J, Adamczyk B, Novokmet M, Polašek O, Gornik O, Šupraha Goreta S, Wormald M.R., Redžić I, Campbell H, Wright A, Hastie N.D., Wilson, J.F., Rudan I, Wuhrer M, Rudd, P.M., Josić D, Lauc G. (2011) High throughput isolation and glycosylation analysis of IgG – variability and heritability of the IgG glycome in three isolated human populations. Mol Cell Proteomics 10(10):M111.010090. (IF=8,354; rank 5/71 – Biochemical Research Methods, median IF = 2,312)

  3. Pivac N, Knežević A, Gornik O, Pučić M, Igl W, Peteers H, Crepel A, Steyaert J, Novokmet M, Redžić I, Nikolac M, Novkovic Hercigonja V, Dodig Ćurković K, Ćurković M, Nedić G, Much-Šeler D, Borovečki F, Rudan I, and Lauc G (2011) Glycosylation of human plasma proteins in attention-deficit hyperactivity disorder and autism spectrum disorders. Mol Cell Proteomics, 10(1):M110 004200 (IF=8,354; rank 5/71 – Biochemical Research Methods, median IF = 2,312)

  4. Igl W, Polašek O, Gornik O, Knežević A, Pučić M, Novokmet M, Huffman J, Gnewuch C, Liebisch G, Rudd PM, Campbell H, Wilson JF, Rudan I, Gyllensten U, Schmitz G, Lauc G (2011) Glycomics meets lipidomics –Associations of N-glycans with classical lipids, glycerophospholipids, and sphingolipids in three European populations, Mol Biosyst, 7(6): 1852-1862. (IF=3,825; rank 97/286 Biochemistry & Molecular Biology – median IF=2.62)

  5. Lauc G, Essafi A, Huffman J, Hayward C, Knežević A, Kattla J, Polašek O, Gornik O, Vitart V, Abrahams JL, Pučić M, Novokmet M, Redžić I, Campbell S, Wild SH, Borovečki F, Wang W, Kolčić I, Zgaga L, Gyllensten U, Wilson JF, Wright AF, Hastie ND, Campbell H, Rudd PM, Rudan I (2010) Genomics meets glycomics - The first GWAS study of human glycome identifies HNF1 as a master regulator of plasma protein fucosylation, PLOS Genetics 6(12): e1001256. (IF=9,543; rank 10/156 – Genetics and Heredity, median IF = 2,488)

  6. Knežević A, Polašek O, Gornik O, Rudan I, Campbell H, Hayward C, Wright A, Kolčić I, O’Donoghue N, Bones J, Rudd PM and Lauc G (2009) Variability, Heritability and Environmental Determinants of Human Plasma N-Glycome. J. Proteome Res. 8:694-701. (IF=5,684; rank 6/65 – Biochemical Research Methods, median IF = 2,312)

  7. Knežević A, Gornik O, Polašek O, Pučić M, Novokmet M, Redžić I, Rudd P.M., Wright AF, Campbell H, Rudan I and Lauc G. (2010) Effects of aging, body mass index, plasma lipid profiles, and smoking on human plasma N-glycans. Glycobiology 20:959-969. (IF=4,45; rank 64/276 Biochemistry & Molecular Biology – median IF=2.62)

  8. Lauc G, Zoldoš V (2010) Protein glycosylation – an evolutionary crossroad between genes and environment, Mol Biosystems, 6(12):2373-2379. (IF=4,23; rank 71/276 Biochemistry & Molecular Biology – median IF=2.62)

  9. Lauc G, Rudan I, Campbell H, Rudd PM (2010) Complex genetics of protein glycosylation. Mol. Biosystems. 6:329-335. (IF=4,23; rank 71/276 Biochemistry & Molecular Biology – median IF=2.62)

  10. Pučić M, Pinto S, Novokmet M, Knežević A, Gornik O, Polašek O, Vlahoviček K, Wang W, Rudd PM, Wright AF, Campbell H, Rudan I and Lauc G. (2010) Common aberrations from normal human N-glycan plasma profile. Glycobiology 20:970-975. (IF=4,45; rank 64/276 Biochemistry & Molecular Biology – median IF=2.62)

  11. Gornik O, Wagner J, Pučić M, Knežević A, Redžić I, Lauc G (2009) Stability of N-glycan profiles in human plasma. Glycobiology 19:1547-53 (IF=4,45; rank 64/276 Biochemistry & Molecular Biology – median IF=2.62)