ACE DNA test

Check if you have a genetic risk of myocardial infarction

ACE (angiotensin converting enzyme) is an enzyme vital to normal human physiology and plays a key role in regulating blood pressure. Studies have shown the association of a risk variant of the ACE gene with hypertension, cardiovascular disease, atherosclerosis, coronary heart disease, stroke and a number of other diseases.

Changes in the ACE gene may cause inadequate response to ACE inhibitors. ACE inhibitors sre used to reduce arterial blood flow and increase venous capacity, increase cardiac output and heart rate.

The ACE DNA test determines the insertion/deletion variance for ACE which is associated with changes in serum ACE activity. Therefore, the result of the test may be particularly significant for people with elevated serum ACE levels.

Consult cardiologist

The decision on therapy cannot be based on this test only; DNA test results should be interpreted in the context of other relevant laboratory tests and clinical information.

Act and prevent

People with a risk variant of the ACE gene can significantly reduce the likelihood of having a heart attack or stroke by changing lifestyle, by avoiding contributing risk factors as well as by regular targeted medical examinations. In people with elevated blood pressure, testing is important in order to receive appropriate medical treatment.

ACE gen affects sport performance

Polymorphism of the ACE gene also determines genetic predisposition for motor and functional abilities associated with sports performance. Gene variants of the ACE gene have impact on the individual’s response to physical activity through the influence of motor and functional abilities such as endurance or strength. Depending on the variant of the ACE gene, there is also an effect on the abilities of the individual to their physical activity program, i.e., to achieve optimal training results.

Understanding the gene response of an individual to physical activity is key to creating an effective personalized exercise program.

When to get tested?

In following cases:

  • increased risk for cardiovascular diseases – a genetic predisposition
  • stress, smoking, overweight and family medical history of cardiovascular diseases
  • risk of hypertension in pregnancy
  • treatment of elevated blood pressure
  • a heart attack or stroke at a younger age
  • when planning to make a personalized approach to physical activity with the aim of achieving optimal training results

In case of an increased ACE serum level, especially for:

  • patients who do not respond to ACE inhibitors
  • patients who had a myocardial infarction
  • individuals with a left ventricular hypertrophy
  • individuals with the Angiotensin II A166C mutation

How does DNA testing for ACE DNA factors work?

The test is performed by DNA analysis from a buccal swab sample and the test is 100% effective.The sampling procedure is painless and it takes only 10-15 seconds.

Gen ACE rs4646994 (In/Del) is analyzed in order to determine genetic predisposition for the risk of myocardial infarction and for better adaptation to strength and speed exercises as well for the better physical endurance. 

How does DNA testing for ACE DNA factors work?

ACE plays a key role in the renin-angiotensin system of blood pressure regulation. It converts angiotensin I into angiotensin II, which is a strong vasopressor. ACE also inactivates bradykinin which is a potent vasodilator.

ACE is the key drug target for treatment of high blood pressure. ACE inhibitors lead to systemic dilatation of the arteries and veins and to a decrease in arterial blood pressure. ACE inhibitors diminish angiotensin II – mediated aldosterone secretion of from the adrenal cortex. This results in a decrease of water and sodium reabsorption and a reduction in extracellular volume.

The ACE gene is located on chromosome 17. Insertion / deletion polymorphism (Ins / Del) of the Alu repeat element in intron 16 of the ACE gene is associated with changes in the serum ACE activity. Allele I indicates the insertion, and allele D indicates the deletion of the repeat element. The ACE levels are higher in individuals homozygous for the D allele, and lowest for individuals homozygous for the allele I.

ACE allele D is associated with a number of disease risks such as myocardial infarction in low risk patients, left ventricular hypertrophy, and progressive diabetic nephropathy. Homozygous genotype DD (deletion of both alleles of homologous chromosomes) indicates a genetic predisposition to significantly increased protein activity, and, consequently, increased risk for disturbed blood pressure regulation and therefore increased risk for stroke.

According to some studies conducted in men with erectile dysfunction, homozygous II have a better response to Viagra, compared to heterozygous DI or homozygous DD.

Insertion in the ACE gene is also associated with better physical endurance (found in top long-distance runners, top mountaineers, rowers, marathon runners etc.). The deletion in this gene is associated with the ability to perform physical activities that require strength and speed.

The frequency of each genotype in the Caucasian population is as follows: the homozygous DD – about 33%, the heterozygous ID – about 45%, and the homozygous II – about 20%

Price of the DNA ACE test:  

ACE rs4646994 (In/Del)                            55,00 EUR

Price is per one sample.

Order form is available here.

Price list is available here.

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